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- 1.Development of Novel Antibacterial Therapeutics
- In general, a pharmaceutical industry use mammals such as mice as testing animals
to evaluate a therapeutic effect for compounds selected through multi-stage
tests in vitro. For that reason, a development of antimicrobic costs and
the efficiency is low. We have invented an innovative technology to explore
effective compounds in bacterial infection such as Methicillin-resistant
Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa using a therapeutic
effect index drived from silkworm larvae infection model. The new method
selects compounds that show a therapeutic effect by silkworm larvae infection
model from actinomycetes and fungi culture supernatant produces substances
that inhibit a pathogen proliferation. We screen compounds pocessing a novel
structure with mouse infection model showing a sufficient therapeutic effect
at last. We have already succeeded in identifying antibiotics shows a therapeutic
effect in mouse infection model. In future, we sell novel compounds with silkworm model to pharmaceutical firms.
- 2.Development of Antiviral Drugs
- In the system of silkworm larvae death by baculovirus infection, Ganciclovir
and Foscarnet that are medical treatment medicine for herpes virus and
Cytomegalovirus infection show a therapeutic effect. With this system,
we develop an evaluation of the effect in new antiviral drugs
for humans. We have already succeeded to produce purified substances
using as an indicator of therapeutic agents in baculovirus-infected silkworm
larvae system from cinnamon. The structure determination by NMR, this compound
was found to be a substance that no antiviral activity was reported. This
substance was also found to inhibit the ability of HSV-1 plaque formation.
And furthermore, we have found a sample that demonstrates a therapeutic effect
in baculovirus-infected silkworm larvae model from fraction of ethanol
extract from the culture of the bacteria that have been isolated from soil.
Currently, we are attempting to purify the active ingredient to determine
- 3.Development of a Method for the Prevention and Treatment of Hay Fever
- In alkaline aqueous solution, cedar pollen causes morphological changes
after an outer shell is removed. The cedar pollen doesn't have an ability
to shedder. Based on the new idea, we have been working on developing new
methods of preventing pollen shedding. We are also working on hay fever
prevention and drug development based on the idea.
- 4.Development of Natural Food
- We have established a system to analyze and extract the active ingredients
from Chinese medicine and health food such as turmeric and its system to
measure an efficacy. Using this system, we are trying to develop new natural
- 5.Development of Method to Test Toxicity and Pathogenicity of Food
- The effective amount (ED50) of antibiotics in humans and silkworms match
and a lethal dose (LD50) of poison per body weight also match. In general,
detection of the toxic food, physico-chemical methods depending on the
type of poison are used, however the coventional method cannot used for
detection of all poisons since unknown poins still exist. Therefore, we
are aiming to develop and commercialize methods to detect pathogenic bacteria
and poisons from Agricultural products, food and environment using silkworms
as experimental animals.
Funded Research using Silkworms as Experimental Animals
- 1.Evaluation of Innate Immune Activation
- ①Evaluation of innate immune activation
This system makes use of muscle contraction of silkworm larvae as an indicator and assesses whether the test compound causes an activation of the innate immune or not.
②Evaluation of the effect of suppressing innate immune
This system makes use of muscle contraction of silkworm larvae as an indicator
for innate immune activation and evaluates an inhibitory effect of the
- 2.Test of Disease Treatment Effect
In pharmaceutical industry, antimicrobial agent development makes use of
marmmals such as mice as experimental animals for evaluation of therapeutic
effect to compounds that are selected through a multi-stage test in vitro.
Therefore, cost and efficiency problems exist. We evaluate therapeutic
effects though silkworm infection model.
- 3.Silkworm Disease Model Development and Funded Research
We have been developing various disease models such as bacteria, fungi
and viruses infection models.